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Yingxue Ren

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Articles

APOE2 attenuates APOE4 -associated amyloid pathology and related toxicity in a mouse model of Alzheimer’s disease

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By Kai Chen, Yixing Chen, Yingxue Ren, Zhen Wang, Ya Huang, Meixia Pan, Zonghua Li, Monica Casey, Wenhui Qiao, Ji Shi, Dehui Kong, Gisela Xhafkollari, Allison M. Wetmore, E. Aubrey Thompson, Xusheng Wang, Dennis W. Dickson, David M. Holtzman, Guojun Bu, Xianlin Han, Junmin Peng, Na Zhao, Hannah Santhakumar
| Nature Verified
Abstract The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD), influencing amyloid-β (Aβ) aggregation, clearance, and glial function. While APOE4 promotes Aβ pathology and APOE2 is protective, how these opposing alleles interact in the heterozygous APOE2/4 state remains unknown.
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Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice

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By Ana-Caroline Raulin, Eunmi Lee, Mingjie Li, Yingxue Ren, Sydney V. Doss, Bhaskar Roy, Lindsey Kuchenbecker, Yuka A. Martens, Chia-Chen Liu, Guojun Bu, Takahisa Kanekiyo, Alla Alnobani, Paula Rodriguez-Martinez, Cynthia Linares, Aria R. Yslas
| Nature Verified
Abstract The rare APOE3-Christchurch (APOE3Ch) variant is linked to resistance against PSEN1 p.E280A-driven autosomal dominant Alzheimer’s disease (AD). Recent studies in AD mouse models have demonstrated an effect of APOE3Ch in reducing tau pathology and tau propagation, yet its effects on amyloid pathology and related toxicity are not fully understood.
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A split biotin ligase approach reveals proteins associated with oligomeric alpha-synuclein during aggregation - Scientific Reports

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By Analiese R. Fernandes, Abigail Owen, Ayman H. Faroqi, Jannifer H. Lee, Gunveen S. Sachdeva, Dmytro Morderer, Benjamin Madden, Shuwen Zhang, Yingxue Ren, Suelen L. Boschen, Akhilesh Pandey, Wilfried Rossoll, Pamela McLean, Cody Hoffmann
| Nature Verified
Abstract Lewy pathology can form over decades in patients with Lewy body diseases, but the causal cellular mechanisms associated with this process remain unclear. This project aims to discover proteins that associate with monomeric and/or oligomeric alpha-synuclein during early stages of the aggregation process.
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