Yingyi Chen

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description lpor71873-sup-0001-SuppMat.docx12.6 MB Supporting File: lpor71873-sup-0001-SuppMat.docx. References 1, “Cutting-Edge Terahertz Technology,” Nature Photonics 1 (2007): 97–105.

Abstract Background and aims: Inflammatory stimuli drive metabolic reprogramming in macrophages, supplying energy, reducing equivalents, and methyl donors required for the production of inflammatory mediators such as IL-1β; however, metabolic strategies to regulate this pathway remain unclear. Here, we aimed to define the mechanism by which D-mannose suppresses one-carbon metabolism in inflammatory macrophages and thereby epigenetically restrains inflammatory responses.

1 Introduction Small dams are abundant and widely distributed across mountainous regions. Hydropower, as a renewable energy source, has gained favour among many countries and investors, leading to rapid development (Dursun and Gokcol 2011; Nautiyal et al. 2011). However, its ecological consequences are well-documented.