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WDR4 drives tumour-associated macrophage reprogramming and tumour progression via selective translation and membrane cholesterol efflux - Nature Cell Biology
Abstract Tumour-associated macrophages (TAMs) play a pivotal role in shaping the immune microenvironment of hepatocellular carcinoma (HCC), influencing tumour progression and immunotherapy response. WDR4, a tRNA-binding cofactor of the N7-methylguanosine (m7G) methyltransferase complex, remains poorly understood in its independent functions. Here we show that WDR4 is significantly upregulated in HCC-associated TAMs and correlates with poor prognosis.
FOXA1‐TET1 Mediate the DNA Hypomethylation of IL‐4 Is Involved in Dust Fall PM2.5 Induced Lung Inflammation
Conflicts of Interest The authors declare no conflicts of interest. References , , , et al. 2022. “Dust Fall PM2.5-Induced Lung Inflammation in Rats Is Associated With Hypermethylation of the IFN-γ Gene Promoter via the PI3K-Akt-DNMT3b Pathway.” Environmental Toxicology and Pharmacology 95: 103942. https://doi.org/10.1016/j.etap.2022.103942. , , , et al. 2023.
Research on State Diagnosis Methods of UHF Partial Discharge Sensors Based on Improved ViT
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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