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Yingyi Yang

As seen in: Wiley Online Library, Science Magazine, Cell Press
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Articles

Metabolic-epigenetic rewiring of CCR5 hi monocytes sustains long-term trained immunity against lethal sepsis

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By Sean Wang, Xibo Wang, Angelo Ruggieri, Lingqi Xu, Wenyan Hao, Yingyi Yang, Yu Wang, Yuan Gong, Yifang Ding, Jie Huang, Zhenjiang Bai, Qiang Shan, Rui Kang, Jiang Wang, Haichao Wang, Timothy R. Billiar, Jian Wang, Daolin Tang, Huiting Zhou, Yaoshuang Li
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Trained immunity enhances innate host defense by endowing monocytes with memory-like properties, yet the underlying integrated metabolic and epigenetic mechanisms remain elusive.
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Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors

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By Jiao Liu, Xiutao Cai, Junhao Lin, Zhenhui Zhang, Qile Zhou, Xiao Zhang, Lifang Ma, Yayou Miao, Ruoxi Zhang, Chunhua Yu, Yingyi Yang, Yangchun Xie, Rui Kang, Daniel J. Klionsky, Peng Liu, Guido Kroemer, Daolin Tang, Jiayi Wang
| Cell Press Verified
Keywords cancer therapy cell death immunogenicity oxidative stress zona pellucida family Get full text access Log in, subscribe or purchase for full access. References 1. Chen, R. ∙ Zou, J. ∙ Liu, J. ... DAMPs in the immunogenicity of cell death Mol. Cell. 2025; 85:3874-3889 2. Kroemer, G. ∙ Galassi, C. ∙ Zitvogel, L. ... Immunogenic cell stress and death Nat. Immunol. 2022; 23:487-500 3. Tang, D. ∙ Kang, R. ∙ Berghe, T.V. ... The molecular machinery of regulated cell death Cell Res. 2019; 29:347-364 4. Ma, M.
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BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis (Adv. Sci. 37/2025)

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By Yuan Gong, Wenyan Hao, Lingqi Xu, Yingyi Yang
| Wiley Online Library Verified
Graphical Abstract Protection Against Polymicrobial Sepsis This artistic illustration depicts how Bacillus Calmette-Guérin (BCG) -derived outer membrane vesicles (OMVs) enhance host defenses by inducing trained immunity. Much like a fortified castle with reinforced walls and vigilant guards, the BCG-OMVs-trained host effectively repels microbial invaders, in contrast to untrained hosts vulnerable to polymicrobial sepsis.
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