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Axillary surgical de-escalation after neoadjuvant therapy in breast cancer: current evidence, clinical controversies, and future directions
Abstract Neoadjuvant therapy (NAT) has expanded opportunities to de-escalate axillary surgery in breast cancer, but the appropriate extent of surgery remains uncertain across pretreatment nodal stages and post-treatment responses.
RNA-Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection
1 Introduction Viral infections pose a persistent threat to global public health, driven by emerging and re-emerging pathogens-such as influenza A Virus (IAV) [1-3] and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that hijack host cellular machinery [4].
The chromosomal instability associated gene C2orf76 exerts dual roles in colorectal cancer through pyroptosis and chemotherapy response
Abstract Introduction: Despite advances in colorectal cancer (CRC) treatment, the chromosomal instability (CIN)-positive subgroup remains refractory to conventional therapies and immunotherapy. C2orf76, a poorly characterized gene identified as a CIN-linked candidate in CRC through bioinformatic analyses, has been associated with favorable prognosis and potential immune-related functions. However, its biological roles and underlying mechanisms in CRC remain largely unexplored.
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