Yingying He
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A revised Köppen climate classification reveals hydrothermal controls on eco-climate over the Qinghai–Tibet Plateau
Abstract The Köppen–Geiger climate classification is widely used to represent global eco-climatic patterns, yet its application to high-altitude regions such as the Qinghai–Tibet Plateau (QTP) remains limited because tundra climates (ET) are defined primarily by temperature, overlooking moisture constraints on vegetation.
HDAC2-Mediated SMAD7 Stabilisation Activates Wnt/β-Catenin Signalling to Drive DNA Damage Repair and Cisplatin Resistance in Ovarian Cancer
1 Introduction Ovarian cancer (OC) is one of the most lethal malignancies of the female reproductive system, with a poor prognosis primarily attributed to difficulties in early diagnosis and the development of chemotherapy resistance, particularly platinum resistance [1]. As a cornerstone drug for advanced OC, carboplatin triggers tumour cell apoptosis through DNA damage, yet the clinical onset of resistance is frequently driven by the activation of robust DNA damage repair pathways [2].
Risk factors for radiation pneumonitis following adjuvant radiotherapy for breast cancer: a retrospective cohort study
Abstract Objective: To delineate the risk factors associated with radiation pneumonitis (RP) in breast cancer patients receiving adjuvant radiotherapy, thereby informing strategies for dosimetric optimization and risk mitigation. Methods: A retrospective analysis was performed on 811 female patients who underwent postoperative radiotherapy for breast cancer to investigate the potential risk factors associated with RP.
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