Yingying He
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ADP-ribose induces neuronal ferroptosis through ENT2-mediated nucleotide rewiring
Abstract Excessive nicotinamide adenine dinucleotide (NAD+) consumption fuels neurological pathogenesis, yet the limited benefit of NAD+ supplementation hints at unresolved toxicity from its catabolism. Here, we identify ADP-ribose, a neglected NAD+ catabolite generated by poly(ADP-ribose) polymerase 1 (PARP1) and poly(ADP-ribose) glycohydrolase, as an inducer of neuronal ferroptosis through nucleotide metabolic rewiring.
Network analysis of hope, medical coping, and self-deficiency in patients with port-wine stain
Abstract Background: Port-wine stain (PWS) is a chronic congenital vascular malformation that often causes substantial psychosocial burden due to visible skin lesions. However, the complex interrelationships among hope, medical coping, and self-deficiency in patients with PWS remain unclear.
A revised Köppen climate classification reveals hydrothermal controls on eco-climate over the Qinghai–Tibet Plateau
Abstract The Köppen–Geiger climate classification is widely used to represent global eco-climatic patterns, yet its application to high-altitude regions such as the Qinghai–Tibet Plateau (QTP) remains limited because tundra climates (ET) are defined primarily by temperature, overlooking moisture constraints on vegetation.
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