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Yingying Liang on Muck Rack

Yingying Liang

As seen in: Nature, Wiley Online Library, Frontiers in Immunology, MDPI, Biomed Central (BMC), Diagnostic Pathology, BioRxiv, Dialnet - Universidad de La Rioja, Academic Radiology
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Articles

Peripheral immune phenotyping identifies an immunosuppressed sepsis endotype with potential relevance for immune stratification

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By Rong Luo, Xiaofan Deng, Chengying Hong, Yingying Liang, Jinquan Xia, Da Zhang, Jingjin Liu, Chunbo Chen, HuaiSheng Chen, Yixia Xie
| Frontiers in Immunology
Abstract Background: Sepsis is characterized by profound immune dysregulation, yet the biological significance and clinical application of peripheral immune phenotyping in sepsis remain incompletely defined. This study aimed to define internally identified immune phenotypes in sepsis and evaluate their prognostic and translational relevance. Methods: In this single-centre retrospective cohort study, 374 adult patients with sepsis or severe infection were included.
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Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

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By Wangting Li, Weihao Gao, LU CHEN, Dong Fang, Lujia Feng, Canfeng Huang, Jia Liang, Yingying Diao, Bingyu Bai, Ting Xie, Pengfeng Li, Huiyan Zheng, Weihua Yang, Xue Yao, Fang Li, Zheng Gong, Zhuo Deng, Wenyong Huang, Bing Zhang, Zixia Zhou, Li Cai, Hongchang Yang, Xiaoshan Fang, Yunxia Leng, Danna Chen, Yingying Liang, Xiaoyan Dou, Haoying Li, Gang Du, Yunwei Hu, Lan Ma, Wei Chi, Shaochong Zhang, Yijing Zhuang, Pengxue Wei, Xiangqing Hei, Xianling Tang, Zengfen Wu, Donghui Pu, Guangbing Zhong, Linyi Luo
| Nature Verified
Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOCT, an intelligent OCT analysis system that integrates a multi-level annotation framework with data distillation to enable automated multi-sectional scan analysis and comprehensive natural language report generation.
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Dual targeting of topoisomerase I and DNA G-quadruplexes enhances senescence and chemosensitivity in colorectal cancer - Communications Biology

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By Yameng Li, Donglei Ji, Yanjie Jia, Yingying Liang, Enwei Wei, Chunfeng Gao, Yongqi Li, Caroline Zeng, Liping Wang, Chunyu Wang, Zhen Guo, Yiqun Zhang, Ming-Ming Zhou, Di Wu, Lei Zeng
| Nature Verified
Abstract Colorectal cancer (CRC) remains a therapeutic challenge due to chemoresistance that limits conventional treatment efficacy. We developed ZBH-01, a camptothecin derivative engineered to target both topoisomerase I (TOP1) and DNA G-quadruplexes (G4s). Unlike irinotecan (CPT-11), which requires metabolic activation, ZBH-01 directly stabilizes TOP1-DNA covalent complexes and preferentially binds the hTERT promoter G4, a regulator of telomere maintenance and oncogenic transcription.
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