Yingying Ma
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Interfacial hydride transfer for dehalogenation with water
Abstract Reductive dehalogenation of organohalides through hydrodehalogenation with water is critical for environmental and chemical industries. Conventional hydrodehalogenation proceeds via electron transfer pathways (e.g., stepwise electron/hydrogen radical transfer, or two-electron transfer followed by protonation), which are often hampered by limited dehalogenation kinetics and selectivity.
Immune dysregulation in chronic diabetic wounds: therapeutic opportunities for healing reprogramming
Abstract Diabetic foot ulcers (DFUs) represent a devastating complication of diabetes mellitus, affecting approximately 25% of diabetic patients and contributing significantly to morbidity, mortality, and healthcare costs worldwide. Chronic non-healing wounds in diabetes are characterized by persistent inflammation, impaired immune cell function, and dysregulated cellular responses.
Safety of Pharmaceutical Nanosuspensions in Drug Delivery: Evidence, Knowledge Gaps, and Safety-By-Design Strategies Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Poor aqueous solubility remains a major barrier to small-molecule drug development. Pharmaceutical nanosuspensions, composed mainly of drug nanocrystals stabilized by small amounts of excipients, can improve dissolution and have been translated into several oral products and long-acting injectables. However, their simple compositions do not make them biologically inert.
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