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Liuying Wang

As seen in: Nature, Wiley Online Library, MDPI, ACS Publications
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Articles

Structural and mechanistic insights into OCTN1-mediated transport and cancer cell proliferation

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By Binghong Xu, Shengjian Liang, Ziyu Wang, Xiaoyu Zhou, Liuying Wang, Xiaoke Liu, Wei Guo, Cheng Zhu, Zhiyong Lou, Yaxin Wang, Qinqin Liang
| Nature Verified
Abstract The Novel Organic Cation Transporter 1 (OCTN1) facilitates the uptake of endogenous metabolites and therapeutic drugs across diverse tissues. Recognized as a key transporter for the antioxidant ergothioneine (ET), OCTN1 also mediates the cellular entry and release of various cationic compounds. Dysregulation of OCTN1 has been implicated in cancer progression and drug interaction.
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Safety of Pharmaceutical Nanosuspensions in Drug Delivery: Evidence, Knowledge Gaps, and Safety-By-Design Strategies Click to copy article link Article link copied!

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By Yingying Ma, Liuying Wang, Yancai Wang
| ACS Publications
Abstract Click to copy section linkSection link copied! Poor aqueous solubility remains a major barrier to small-molecule drug development. Pharmaceutical nanosuspensions, composed mainly of drug nanocrystals stabilized by small amounts of excipients, can improve dissolution and have been translated into several oral products and long-acting injectables. However, their simple compositions do not make them biologically inert.
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An interpretable deep learning biomarker for prognostication and prediction of adjuvant chemotherapy benefit in gastric cancer

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By Jianxin Ji, Xuan Zhang, Meng Wang, Huiying Li, Xiaohan Zheng, Liuying Wang, Hesong Wang, Yongzhen Song, Jia He, Yong Cao, Qi Zhang, Yaru Wang, Huimin Zhang, Shenghan Lou, Peng Han, Lei Cao, Menglei Hua, Ruihao Qin, Kaiyuan Ge
| Nature Verified
Abstract Prognostic stratification in gastric cancer (GC) currently relies on the tumour-node-metastasis (TNM) staging system, which incompletely captures tumour heterogeneity. Routine haematoxylin and eosin (H&E)-stained whole-slide images (WSIs) contain additional prognostic information that is not routinely quantified.
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