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Safety of Pharmaceutical Nanosuspensions in Drug Delivery: Evidence, Knowledge Gaps, and Safety-By-Design Strategies Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Poor aqueous solubility remains a major barrier to small-molecule drug development. Pharmaceutical nanosuspensions, composed mainly of drug nanocrystals stabilized by small amounts of excipients, can improve dissolution and have been translated into several oral products and long-acting injectables. However, their simple compositions do not make them biologically inert.
An interpretable deep learning biomarker for prognostication and prediction of adjuvant chemotherapy benefit in gastric cancer
Abstract Prognostic stratification in gastric cancer (GC) currently relies on the tumour-node-metastasis (TNM) staging system, which incompletely captures tumour heterogeneity. Routine haematoxylin and eosin (H&E)-stained whole-slide images (WSIs) contain additional prognostic information that is not routinely quantified.
Amide Bond‐Induced Charge‐Directed Transport: Constructing Capture‐Release Networks for Enhanced Electromagnetic Wave Attenuation
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm72600-sup-0001-SuppMat.docx10.6 MB Supporting Information adfm72600-sup-0002-Supportingvideo.mp4859 KB Supporting Information References 1, , , , , , , , , Adv. Mater. 2024, 36, 2403322. 2, , , , , , Adv. Sci. 2019, 6, 1801057. 3, , , , , , , Adv. Funct. Mater. 2025, 10644. 4, , , , , , , , Carbohydr. Polym. 2025, 356, 123418. 5, , , , , , , , Carbon 2025, 238, 120244. 6, , , , , , , , Chem. Eng. J.
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