Yingying Qu

Keywords T cell activation butyrophilins Vγ9Vδ2 T cell receptor phosphoantigen germline-encoded region CDR3 molecular glue dual-ligand recognition innate and adaptive immunity Get full text access Log in, subscribe or purchase for full access. References 1. Rossjohn, J. ∙ Gras, S. ∙ Miles, J.J. ... T cell antigen receptor recognition of antigen-presenting molecules Annu. Rev. Immunol. 2015; 33:169-200 2. Vantourout, P. ∙ Hayday, A. Six-of-the-best: unique contributions of γδ T cells to immunology Nat. Rev.

Abstract Human Vγ9Vδ2 T cells detect cancerous and pathogen-infected cells through an "inside-out" mechanism wherein intracellular domains of butyrophilin (BTN) proteins recognize phosphoantigens (pAgs) to prime BTN ectodomains to engage with the T cell receptor (TCR) to activate Vγ9Vδ2 T cells.

ORIGINAL ARTICLE Yingying Qu and Mengyao Wang contributed equally to this work. Abstract Background Lysosomal cathepsin D (CTSD) can degrade internalized advanced glycation end products (AGEs) in dermal fibroblasts. CTSD expression is decreased in photoaged fibroblasts, which contributes to intracellular AGEs deposition and further plays a role in AGEs accumulation of photoaged skin. The mechanism under downregulated CTSD expression is unclear.