Yingyu Qin on Muck Rack

Yingyu Qin

As seen in: Nature
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Articles

MSTO1 modulates RAD51 activity to safeguard mitochondrial DNA integrity and control immune responses

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By Kaiqi Cheng, Zhanzhan Xu, Jiansong Liu, Yichen Pan, Chen Nie, Zuchao Mao, Haodong Lin, Yingyu Qin, Shuqi Cao, Xiaoman Li, Weibin Wang, Shiwei Li, Jiadong Wang
| Nature
Abstract Pathogenic MSTO1 mutations cause cerebellar ataxia and congenital myopathy, yet their molecular mechanisms remain poorly understood. This study identifies MSTO1 as a crucial regulator of mitochondrial genome integrity through direct interaction with RAD51. MSTO1 deficiency enhances RAD51 binding to mitochondrial DNA (mtDNA), disrupting mtDNA replication and causing mtDNA damage.
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