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Yingyu Zeng

As seen in: Nature, Wiley Online Library, BioRxiv
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Articles

Foamy microglia link oxylipins to disease progression in multiple sclerosis

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By Xinyu Di, Tatiana M. Shamorkina, Anto Pavlovic, Yingyu Zeng, Will Macnair, J. Chen, Hendrik J. Engelenburg, Dennis D. Wever, Berend Gagestein, Elise Dusseldorp, Marco van Eijk, Uwe Grether, Amy C. Harms, Thomas Hankemeier, Ludovic Collin, Albert J. R. Heck, Inge Huitinga, Daan van der Vliet, Claire Coulon-Bainier, Iris A. C. M. van der Vliet, Noëlle van Egmond, Aletta M. R. van den Bosch, Wouter P. F. Driever, Mario van der Stelt
| Nature Verified
Abstract Multiple sclerosis (MS) is a chronic neuroinflammatory disease in which demyelinating white matter lesions accumulate and expand, driving irreversible disability. Here we identify a distinct population of foamy GPNMB+ microglia/macrophages associated with lesion expansion in secondary progressive MS.
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Strontium‐Doped Implant Osseointegration Under Dry Preservation Conditions: In Vitro and Rat Model‐Based In Vivo Studies

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By Jimin Jiang, Yingyu Zeng, Fangyuan Cai, Tianning Ye
| Wiley Online Library Verified
Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
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Foamy microglia link oxylipins to disease progression in multiple sclerosis

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By Xinyu Di, Tatiana M. Shamorkina, Anto Pavlovic, Yingyu Zeng
| BioRxiv
Abstract Multiple sclerosis (MS) is a neuroinflammatory disease characterized by expanding demyelinating lesions, leading to severe and irreversible disability. The mechanisms driving lesion expansion, however, remain poorly understood. Here, using a multi-omics approach, we identified foamy microglia as primary contributors to the molecular profile of lesions and disease progression in secondary progressive MS.
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