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Enterocytes rely on purine biosynthesis/salvage pathway to facilitate dietary fat absorption
Abstract Dietary fat absorption is among the most energy-demanding processes of nutrient uptake. Fatty acid activation, triglyceride synthesis, and the trafficking of chylomicrons through the secretory pathway - all require ATP. How enterocytes accommodate the surge in ATP consumption following fat uptake is unclear. We show that the purine biosynthesis/salvage pathway supplies necessary ATP and that Ankyrin Repeat Domain 9 (ANKRD9) couples ATP synthesis and lipoprotein trafficking.
Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites
Footnotes Received August 9, 2024. Accepted September 10, 2024.
Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites
Abstract Millions of people globally are exposed to the proven human carcinogen arsenic at unacceptable levels in drinking water. In contrast, arsenic is a poor rodent carcinogen, requiring >100-fold higher doses for tumour induction, which may be explained by toxicokinetic differences between humans and mice.
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