Yingze Zhu
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Cyclin-dependent kinase 4 and 6 inhibitors and the breast cancer immune ecosystem: immune remodeling, resistance, and therapeutic reprogramming
Abstract Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6 inhibitors) combined with endocrine therapy have become a therapeutic backbone for hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer, yet durable disease control is frequently limited by intrinsic and acquired resistance.
Dietary quality across the life course and metabolic syndrome: evidence from two decades of follow-up in rural China young adults
Abstract Background: The global prevalence of metabolic syndrome (MetS) among young adults has reached 17.4%. We examined associations of three dietary indices and life-course dietary quality trajectories with MetS and its components using a birth cohort. Methods: Participants from rural western China were followed at four time points: infancy, school age, adolescence, and young adulthood (mean age 20 years).
Maternal Gestational Weight Status and Offspring Physical Growth Status at Birth, Mid‐Childhood and Early Adolescence
1 Introduction Childhood physical growth is a crucial determinant of lifelong health and well-being (Meyer et al. 2021). Understanding the early-life determinants of these growth is vital for informing public health strategies aimed at improving child and adult health outcomes. Maternal nutritional status before and during pregnancy has been identified as a significant determinant of offspring anthropometric indicators (Aune et al. 2014; Kominiarek and Peaceman 2017).
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