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Yingzhi Cui on Muck Rack

Yingzhi Cui

As seen in: Nature, Cell Stem Cell
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Articles

RNA sequestration in P-bodies sustains myeloid leukaemia - Nature Cell Biology

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By Srikanth Kodali, Ludovica Proietti, Gemma Valcarcel, Anna V Lopez-Rubio, Patrizia Pessina, Thomas S. Eder, Junchao Shi, Annie Jen, Núria Lupión-Garcia, Yingzhi Cui, Caroline Sands, Alba Martinez, Talia Velasco-Hernandez, Laureano Tomás-Daza, Bernhard Alber, Isabella Maria Mayer, Karoline Kollmann, Alessandro Fatica, Biola M. Javierre, Joshua Coon, Qi Chen, Jose L. Sardina, Florian Grebien
| Nature Verified
Abstract Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through genome-wide CRISPR screens in normal and malignant haematopoietic progenitors. We found that leukaemia cells harbour aberrantly elevated numbers of P-bodies and show that P-body assembly is crucial for initiation and maintenance of AML.
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Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency

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By Masaki Kinoshita, Michael Barber, William Mansfield, Yingzhi Cui
| Cell Stem Cell Verified
Highlights • Derivation of mouse formative pluripotent stem cells from pre-gastrulation epiblast • Formative stem cells are competent for germline induction • Formative stem cells can contribute to chimeras • Candidate human FS cells derived using similar culture conditions to mouse Summary Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for germline and soma formation, and then undergo lineage priming.
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