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Saving face: why facial scars are smaller than back scars
NEWS AND VIEWS 14 April 2026 Facial wounds heal with less scarring than do comparable ones on the back. The reason relates to differences in the ability of cells to express collagen genes. A scar is a physical mark of a healed wound and a sign of an event that can live on in memory. In Shakespeare’s play Henry V, the king makes a speech to rouse his troops on the eve of battle.
PFKM governs metabolic shifts throughout skeletal muscle differentiation - Nature Metabolism
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Abstract Metabolism is known to influence cell identity, but the underlying mechanisms remain unclear. Here we reveal spatiotemporal dynamics of phosphofructokinase 1 (PFK1), a key glycolytic enzyme, within the skeletal muscle lineage. The expression of PFKM (the muscle isoform of PFK1) is low in muscle stem cells and increases during differentiation.
By Melissa Campos, Steven Nguyen, Xiangduo Kong, Ying Yang, Richard Watson, Anastasia Gromova, Catherine R. Livelo, Carolina Franco, Julia Cabral, Laurence J. Seabrook, Shengqi Dai, Yingzi Liu, Mingqi Zhou, Eric A. Hanse, Kaelyn Sumigray, Albert La Spada, Marcus M. Seldin, Maksim V. Plikus, Dequina Nicholas, Reginald McNulty, Mei Kong, Kyoko Yokomori, Lauren Albrecht
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Neuronal PPP2R5C in plasma is a potential biomarker for early diagnosis of Alzheimer’s disease
Results To explore the specific early diagnostic markers of AD in neurons, we isolated NDEs from plasma in cohort 1. Transmission electronic microscopy (TEM) images showed the morphology of NDEs (Figure 1A), and the particle size of TEM matched with the nanoparticle tracking analysis, displaying the size of NDEs to be distributed mainly between 70 and 150 nm (Figure 1B).
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