Yining Zhou
As seen in:
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Wiley Online Library,
arXiv,
MDPI,
Taylor & Francis Online,
Journal of Sensors,
No Film School,
The Lantern
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Skeletal Muscle–Derived Extracellular Vesicles During Eccentric and Concentric Exercise Promote Muscle Regeneration After Injury
1 Introduction Skeletal muscle injuries are prevalent in both athletic and general populations, often resulting from acute trauma or repetitive strain [1], and leading to severely restricted limb activity. Recent evidence-based clinical studies [2] have shown that muscle contraction exercises, including eccentric exercise (EE) and concentric exercise (CE) [3], can effectively promote muscle repair [4]. EE generates higher mechanical tension with lower metabolic cost than CE.
Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia
Abstract Exercise confers cognitive benefits in Alzheimer’s disease (AD), yet the underlying mechanisms remain incompletely understood. Skeletal muscle functions as an endocrine organ that secretes myokines which affect the homeostasis of extra-muscular organs, including the brain. Here we found that swimming exercise promotes secretion of skeletal muscle-derived extracellular vesicles (SKM-EVs), which are subsequently taken up via pinocytosis by microglia.
A Unified Reinforcement Learning Framework for Dynamic User Profiling and Predictive Recommendation
This version is not peer-reviewed. Submitted: 14 October 2025 You are already at the latest version This paper proposes a unified modeling approach based on reinforcement learning to address the problem of dynamic user profiling and behavior prediction.
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