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C-glycoside synthesis via radical cross-coupling of glycohydrazides
Abstract Carbohydrates are among the most abundant and structurally diverse biomolecules in nature, playing central roles in energy storage, molecular recognition, and cell signaling. Within this domain, C-glycosides1-3, in which the oxygen atom of the glycosidic bond in O-glycosides is replaced by carbon, have emerged as valuable motifs in medicinal chemistry due to their resistance to enzymatic hydrolysis2,4.
Scalable total synthesis of saxitoxin and related natural products - Nature
Abstract Saxitoxin (STX, 1), a potent neurotoxin from shellfish, first isolated in 19571, offers immense pharmaceutical potential due to its interaction with voltage-gated sodium channels2, that are ubiquitously present in all excitable cells of the central and periphperal nervous system3. Hundreds of synthetic studies towards this end have been disclosed thus far, yet, a fully modular and scalable approach to the family remains elusive4-12.
Total Synthesis of Dynobactin A
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
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