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C-glycoside synthesis via radical cross-coupling of glycohydrazides
Abstract Carbohydrates are among the most abundant and structurally diverse biomolecules in nature, playing central roles in energy storage, molecular recognition, and cell signaling. Within this domain, C-glycosides1-3, in which the oxygen atom of the glycosidic bond in O-glycosides is replaced by carbon, have emerged as valuable motifs in medicinal chemistry due to their resistance to enzymatic hydrolysis2,4.
Stereoretentive radical-based alkyl-alkyl cross-coupling
Editor’s summary Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Chemical bond-forming reactions fall into two categories: ionic mechanisms with electron pair intermediates and radical mechanisms with unpaired electrons. Generally, the radical intermediates have fluctuating configurations and so tend to deliver two mirror-image products. Wang et al.
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