Yinnian Feng

Keywords histidine scanning TCR TCR-T cell therapy catch bond cancer immunotherapy Notch FcR MAGE-A3 WT-1 TAK1 Get full text access Log in, subscribe or purchase for full access. References 1. Jenkins, M.K. ∙ Chu, H.H. ∙ McLachlan, J.B. ... On the Composition of the Preimmune Repertoire of T Cells Specific for Peptide–Major Histocompatibility Complex Ligands Annu. Rev. Immunol. 2010; 28:275-294 2. Qi, Q. ∙ Liu, Y. ∙ Cheng, Y. ... Diversity and clonal selection in the human T-cell repertoire Proc. Natl. Acad.

Abstract αβT-cell receptors (TCRs) recognize aberrant peptides bound to major histocompatibility complex molecules (pMHCs) on unhealthy cells, amplifying specificity and sensitivity through physical load placed on the TCR-pMHC bond during immunosurveillance. To understand this mechanobiology, TCRs stimulated by abundantly and sparsely arrayed epitopes (NP366-374 /Db and PA224-233/Db, respectively) following in vivo influenza A virus infection were studied with optical tweezers.

Lys256 controls the TCRαTM depth and CD3 homo- and heterodimer associations The TCRα transmembrane (TM) domain is a bipartite helix separated by a dynamic hinge Initial molecular details of cellular activation following αβT cell antigen receptor (TCR) ligation by peptide-major histocompatibility complexes (pMHC) remain unexplored.