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PTGER4 promoter methylation may serve as an independent prognostic biomarker and is associated with response to hypomethylating agents in pediatric acute myeloid leukemia
Abstract Background: Despite advances in therapy, 30%–40% of pediatric acute myeloid leukemia (AML) patients still experience treatment failure due to relapse or toxicity. Current risk stratification based on genetic features remains insufficient, and epigenetic biomarkers for pediatric AML are understudied. This study aimed to evaluate the prognostic and predictive value of PTGER4, SHOX2, and HOXA9 promoter methylation in pediatric AML.
Global prevalence of chronic kidney disease in type 1 diabetes: A systematic review and meta‐analysis
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. PEER REVIEW The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/dom.70378. DATA AVAILABILITY STATEMENT The data analysed in this study are derived from previously published studies, which are cited in the manuscript. The original datasets can be accessed from the corresponding authors of the included studies upon reasonable request.
Reinventing product-service systems: the case of Singapore
Author(s): Sarah Lai-Yin Cheah , (Department of Management and Organization, National University of Singapore, Singapore, Singapore) Yinping Yang , (Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore) ...Show all authorsAbstract: This paper aims to discuss a foresight study conducted in Singapore’s national R&D agency to help science and technology decision makers identify key capability areas of R&D investment to support...
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