Yinsheng Wang
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NAE1/UBA3-UBE2M are E1 and E2 enzymes for the URM1 modification
Abstract Ubiquitin-related modifier 1 (URM1) is an evolutionarily conserved ubiquitin-like protein. In eukaryotes, it serves dual roles as a sulfur donor for tRNA modification and a posttranslational protein modifier. URM1 is proposed to be a primitive protein modifier and a potential precursor to the more complex ubiquitin system. However, no specific activating enzyme (E1), conjugating enzyme (E2), or ligase (E3) has been reported for the URM1 modification cascade in human cells.
TRMU Confers Resistance of Melanoma Cells to Vemurafenib through Modulating Mitochondrial Activities
Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse
Keywords meninges neuroinflammation autoimmune disease B cells EAE antigen presentation GM-CSF Endothelial cell vascular inflammation Get full text access Log in, subscribe or purchase for full access. References 1. Alves de Lima, K. ∙ Rustenhoven, J. ∙ Kipnis, J. Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease Annu. Rev. Immunol. 2020; 38:597-620 2. Magliozzi, R. ∙ Howell, O. ∙ Vora, A. ...
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