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Yintian Liu on Muck Rack

Yintian Liu

As seen in: Nature
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Articles

Efficient and precise programmable DNA knock-in without double-strand breaks

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By Yanmin Gao, Yu Ma, Kexin Yu, Hao Tang, Wenjie Yan, ShuangShuang Yang, Xindong Wang, Xin Ma, Fang Wang, Qingyang Li, Mengying Liu, Haifeng Wang, Yintian Liu, Buming Gu, Jingran Su
| Nature Verified
Abstract Programmable gene knock-in holds substantial promise for treating genetic diseases and advancing cell therapies. However, achieving precise and efficient kilobase-scale DNA fragment integration remains challenging1,2. Here we report CRISPR kilobase-scale nickase-targeting (KNIT) editing for efficient, precise and programmable kilobase-scale DNA insertion without double-strand DNA cleavage, which is enabled through the coupling of a Cas9 nickase with a DNA donor recruiting system.
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