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Mengying Liu on Muck Rack

Mengying Liu

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Articles

Time-resolved multi-omics reveals macrophage-centered immunometabolic remodeling in cutaneous dematiaceous fungal infection

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By Yongqiang Fu, Mengying Liu, Qi Dong, Xinyu Guo, Jiejie Lu, Weiwei Wu, Hiroki Takahashi, Ruijun Zhang
| Frontiers in Immunology
Abstract Background: Dematiaceous fungi cause chronic, invasive cutaneous infections that are difficult to eradicate and frequently relapse despite antifungal therapy. Although host immunity is critical for controlling these infections, the temporal organization of immune responses and the underlying immunometabolic programs remain poorly defined. In particular, how macrophage dynamics and chemokine signaling shape antifungal immunity over time is largely unknown.
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Efficient and precise programmable DNA knock-in without double-strand breaks

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By Yanmin Gao, Yu Ma, Kexin Yu, Hao Tang, Wenjie Yan, ShuangShuang Yang, Xindong Wang, Xin Ma, Fang Wang, Qingyang Li, Mengying Liu, Haifeng Wang, Yintian Liu, Buming Gu, Jingran Su
| Nature Verified
Abstract Programmable gene knock-in holds substantial promise for treating genetic diseases and advancing cell therapies. However, achieving precise and efficient kilobase-scale DNA fragment integration remains challenging1,2. Here we report CRISPR kilobase-scale nickase-targeting (KNIT) editing for efficient, precise and programmable kilobase-scale DNA insertion without double-strand DNA cleavage, which is enabled through the coupling of a Cas9 nickase with a DNA donor recruiting system.
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March 2026 issue first authors

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By Morgan Barnes, Taoqian Zhao, Wanlin Ye, Mengying Liu, Simon Hasinger, Nadia B. Pedersen, Rajan Thapa
| Cell Press Verified
TrendsTalk | Series: Meet the first authorsOnline now Affiliations & Notes 1Collaborations Pharmaceuticals, Inc., 1730 Varsity Drive, Suite 360, Raleigh, NC 27606-5228, USA 2Department of Radiology and Imaging Science, Emory University, Atlanta, GA, USA 3School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, PR China 4Duke-NUS Medical School, Singapore 169857, Singapore 5Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria...
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