Yinwen Liang

eLife Assessment This valuable study provides insights into the role of Pten mutations in SHH-medulloblastoma, by using mouse models to resolve the effects of heterozygous vs homozygous mutations on proliferation and cell death throughout tumorigenesis.

Editor’s summary Cilia are structures found on the surface of most cells that serve critical functions such as generating fluid flow in the lungs and enabling communication between cells. Genetic mutations that disrupt cilia cause developmental abnormalities called ciliopathies. Transcriptional regulation of cilia formation is poorly understood. Liang et al.

Dephosphorylation of FLA8/KIF3B Is Regulated by Okadaic-Acid-Sensitive Phosphatases, but Not PP2A Both CrPP1 and CrPP6 Participate in FLA8 Dephosphorylation Double Depletion of CrPP1 and CrPP6 Leads to Elevation of pFLA8 in Steady-State Cells and Short Flagella As PP1 is a target of okadaic acid and PP6 is a potential target of okadaic acid that regulates aurora A (AURKA), a kinase involved in ciliary functions [20xProtein phosphatase 6 regulates mitotic spindle formation by controlling the...