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Yinxue Wang

As seen in: Nature, BioRxiv, Cell Press
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Articles

Ginsenoside Rb1 alleviates uterine aging via AMPK-mediated mTOR inactivation

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By Ping Zhou, Yue Wang, Ming Cheng, Feng Deng, Ke Ning, Dan Mo, Zhonghong Zeng, Ziying Huang, Yinxue Wang, Chao Zhang, Jie Qiao, Yang Yu, Heng Pan, Rong Li, Fenting Liu, Xiunan Chen, Yunshu Dong
| Nature Verified
Abstract Uterine aging impairs fertility and reproductive health, but the underlying pathogenic mechanisms and effective treatment strategies remain elusive. Defective endometrial decidualization and implantation failure are hallmarks of uterine aging, which can be driven by cellular senescence, especially in endometrial stromal cells (EnSCs). Rb1 has been reported to relieve cellular senescence by suppressing oxidative and inflammatory pathways.
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An Efficient and Principled Model to Jointly Learn the Agnostic and Multifactorial Effect in Large-Scale Biological Data

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By Zuolin Cheng, Yinxue Wang, Yizhi Wang, Songtao Wei
| BioRxiv
Abstract The rich information contained in biological data is often distorted by multiple interacting intrinsic or extrinsic factors. Modeling the effects of these factors is necessary to uncover the underlying true signals.
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Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model

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By Yizhi Wang, Grace O. Mizuno, Yinxue Wang, Guilai Shi
| Cell Press Verified
Generation and Differentiation of Astroglia from Human Ts21 iPSCs   Spontaneous Ca2+ Fluctuations in DS Astroglia Are Not Driven by Extracellular Cues Combining human stem cell technology with Ca2+ imaging and quantitative analysis tools provides a powerful platform to study neuron-astrocyte interaction in both physiological and pathological conditions, especially at early developmental stages.
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