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Yinyan Sun on Muck Rack

Yinyan Sun

As seen in: Science Magazine, Cell Press, American Society for Microbiology (ASM)
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Articles

Discovery of TYR inhibitors from de novo molecular generation to dual-track lead optimization: “Competition” between AI and chemists

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By Andrea Cimolato, Tahnee Mackensen, Wenqi Pan, Yinyan Sun, Jiahui Wang, Wenchao Chen, Xiaoying Jiang, Shan Wang Verified, Jia Zhi, Feifan Li, Meiling Feng, Xiaotian Niu, Bin Ju, Jianan Guo, Renren Bai
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract This study introduces a unified framework combining artificial intelligence (AI)–directed de novo molecular generation with dual-track lead optimization—comprising expert-guided strategies and AI-driven pathways—to discover tyrosinase (TYR) inhibitors for hyperpigmentation disorders.
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Scavenger receptor class F member 2 is an intracellular receptor for hepatitis B virus

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By Cong Li, Yixue Wang, Rui Xiong, Qiaoyi Li Verified, Zhongmin Zhou, Qingmei Liu, Yonghe Qi, Zihao Gao, Guangwei Xu, Linqiang Fang, Yinyan Sun, Michael Farzan, Hyeryun Choe, Jianhua Sui, Wenhui Li
| Cell Press Verified
Keywords hepatitis B virus intracellular receptor SCARF2 endosome nuclear pore complex nucleocapsid release Get full text access Log in, subscribe or purchase for full access. References 1. Razavi-Shearer, D. ∙ Gamkrelidze, I. ∙ Nguyen, M.H. ... Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study Lancet Gastroenterol. Hepatol. 2018; 3:383-403 2. Heermann, K.H. ∙ Goldmann, U. ∙ Schwartz, W. ...
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Discovery of Novel Dihydroxyphenol Tyrosinase Inhibitors for Treatment of Pigmentation: From Enzyme Screening to Three-Dimensional Human Skin Melanin Evaluation

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By Jiahui Wang, Yinyan Sun, Xiaoying Jiang, Hong Cai
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