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Yinzhen Liu

As seen in: Nature, Cell Press
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Articles

Cryo-EM Structure of the TRPC1/5 Heteromer Enables Design of Antidepressant and Anxiolytic Drug with Reduced Side Effects

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By Yixiang Chen, Xinyu Cheng, Xiaoqiang Yang, Xiaojing Song, Juncheng Li, Ying Fu, Wei Zhang, Sijia Lv, TingTing Yang, Qi Peng, Weiwei Nan, Shuangyan Wan, Yaoguang Hua, Xiaoyun Wu, Han Hu, Yuting Zhang, Yinzhen Liu, Mingxing Yang, Shuqi Zeng, Ougen Liu, Bo Yu, Jingjing Duan, Jian Li, Bing Xiong, Jin Zhang
| Nature Verified
Abstract The TRPC1/5 heteromer exhibits electrophysiological and ligand-binding properties distinct from TRPC5 homomers, enabling tissue-specific cellular regulation. Here we present the cryo-EM structure of the TRPC1/5 heterotetramer at 2.8 Å resolution, revealing an asymmetric assembly of three TRPC5 subunits around one TRPC1 subunit.
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Cryo-EM structure enabling virtual screening for the discovery of highly potent TRPM3 antagonists with analgesic efficacy

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By TingTing Yang, Hongmin Guo, Xinyu Cheng, Mingyang Wang, Sijia Lv, Xiaoqiang Yang, Xiaoyun Wu, Yinzhen Liu, Hui Liu, Han Hu, Wenlu Li, Shuangyan Wan, Haoxiang Peng, Weiwei Nan, Yuting Zhang, Bo Zeng, Erwin Neher, Ougen Liu, Bo Yu, Fengxian Li, Guilin Li, Jian Li, Jingjing Duan, Jin Zhang
| Cell Press Verified
Keywords TRPM3 cryo-EM structure-based drug discovery pain Get full text access Log in, subscribe or purchase for full access. References 1. Finnerup, N.B. ∙ Kuner, R. ∙ Jensen, T.S. Neuropathic Pain: From Mechanisms to Treatment Physiol. Rev. 2021; 101:259-301 2. Rosenberger, D.C. ∙ Blechschmidt, V. ∙ Timmerman, H. ... Challenges of neuropathic pain: focus on diabetic neuropathy J. Neural Transm. (Vienna). 2020; 127:589-624 3. Bouhassira, D. Neuropathic pain: Definition, assessment and epidemiology Rev.
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