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Yogeeshwar Ajjugal on Muck Rack

Yogeeshwar Ajjugal

As seen in: The Journal of Biological Chemistry
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Articles

A B-Z junction induced by an A … A mismatch in GAC repeats in the gene for cartilage oligomeric matrix protein promotes binding with the hZαADAR1 protein

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By Narendar Kolimi, Yogeeshwar Ajjugal, Thenmalarchelvi Rathinavelan
| The Journal of Biological Chemistry Verified
GAC repeat expansion from five to seven in the exonic region of the gene for cartilage oligomeric matrix protein (COMP) leads to pseudoachondroplasia, a skeletal abnormality. However, the molecular mechanism by which GAC expansions in the COMP gene lead to skeletal dysplasias is poorly understood. Here we used molecular dynamics simulations, which indicate that an A … A mismatch in a d(GAC) ·d(GAC) duplex induces negative supercoiling, leading to a local B-to-Z DNA transition.
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A B−−Z junction induced by an A...A mismatch in GAC repeats in the gene for cartilage oligomeric matrix protein promotes binding with the hZαADAR1 protein

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By Thenmalarchelvi Rathinavelan, Narendar Kolimi, Yogeeshwar Ajjugal, IIT Hyderabad
| The Journal of Biological Chemistry Verified
GAC repeat expansion from five to seven in the exonic region of the gene for cartilage oligomeric matrix protein (COMP) leads to pseudoachondroplasia, a skeletal abnormality. However, the molecular mechanism by which GAC expansions in the COMP gene lead to skeletal dysplasias is poorly understood. Here, we used MD simulations which indicate that an A...A mismatch in a d(GAC)6.d(GAC)6 duplex induces negative supercoiling, leading to a local B?to?Z DNA transition.
Open in Who Shared Issue with article?
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