Yong Han

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Abstract Impaired cell proliferation causes fibrotic changes in tissues, leading to loss of function. Although exocyst component 5 (Exoc5), a central component of the eight-protein exocyst complex, regulates the targeting and docking of intracellular vesicles which are essential for cell proliferation, its role in tissue regeneration remains to be defined.

Abstract Fibrosis, an undesirable side effect of the repair process, is due to aberrant cell differentiation and is a typical cause of progressive diseases including chronic kidney disease (CKD). Exocyst complex component 5 (Exoc5), a central component of the highly-conserved eight-protein exocyst complex, is involved in cell differentiation and maturation; however, the role of Exoc5 in fibrosis remains to be defined.