Yoon Hwan Chang

Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is a tick-borne virus that can cause severe infection characterized by inflammation and the loss of immune cells and platelets.

Monocytes are mononucleated nondividing white blood cells derived from bone marrow (BM) progenitors. They are components of the Mononuclear Phagocyte System (MPS), a term introduced by van Furth and Cohn in 1968 [1]. Since Metchnikoff's seminal description of macrophages (from Greek “big eater cells”) in 1908, our understanding has evolved to recognize now that monocytes, together with granulocytes and dendritic cells, all originate from myeloid precursors and are part of the MPS [2].

Atypical lymphocytes (ALYs) are activated lymphocytes with distinct morphological characteristics, often observed in various infections, autoimmune diseases, drug reactions, and malignancies. Their appearance may resemble leukemic or lymphoma cells, making it essential to differentiate ALYs, particularly in patients with hematological malignancies.