JACC Journals › JACC: Heart Failure › Archives › Vol. 13 No. 10 Leading Edge Commentary : JACC: Heart Failure Volume 13, Number 10 Get full access to this article View all available purchase options and get full access to this article. References 1. Virani S.S., Alonso A., Aparicio H.J., et al. Heart disease and stroke statistics—2021 update: a report from the American Heart Association: a report from the American Heart Association. Circulation. 2021;143:e254-e743. 2.