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Articles by Youjun Wang
TMEM184 proteins are Ca 2+ uptake transporters in lysosomes
Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Editor’s summary Inside every cell, lysosomes act as waste-processing centers, and calcium release helps them break down waste and restore themselves if damaged. However, how these organelles replenish their calcium remains unclear. Cai et al.
Calcium-mediated calreticulin-IRE1α interaction drives dynamic fluctuation of IRE1α activity under chronic endoplasmic reticulum stress
Abstract The unfolded protein response (UPR) triggered by endoplasmic reticulum (ER) stress can be both pro-survival or pro-apoptotic, depending on the duration and intensity of the stress. ER stress under (patho)physiological conditions can last for long time, yet the dynamic regulation of the UPR under prolong ER stress is largely unknown.
GPAT4 sustains endoplasmic reticulum homeostasis in endocardial cells and safeguards heart development - Nature Communications
Abstract The endocardium plays a pivotal role in governing myocardial development, and understanding the intrinsic regulatory insights will help apprehend pathological cardiomyopathy. Glycerol-3-phosphate acyltransferase 4 (GPAT4) is an endoplasmic reticulum (ER) membrane anchored protein. While the role of GPAT4 in glycerophospholipid biosynthesis is well established, its function in the ER is less explored.
Preferential allosteric modulation of Otop1 channels by small molecule compounds - Communications Biology
Abstract The Otopetrin (Otop) proteins, comprising Otop1-3, are proton-gated proton channels with key biological functions. Otop1 acts as a receptor for sour and ammonium salt tastes in mammals, but its gating mechanisms and pharmacology remain poorly understood.
Ca2+/calmodulin-dependent protein kinase II β decodes ER Ca2+ transients to trigger autophagosome formation
Keywords CaMKIIβ Ca2+ transient FIP200 liquid-liquid phase separation autophagosome Introduction Ca2+ acts as a versatile signal to control a myriad of cellular activities.1,2 Ca2+ signals are transduced through various Ca2+-binding effectors1 and also multiple Ca2+ or Ca2+/calmodulin (CaM)-dependent protein kinases (CDPKs or CaMKs) that phosphorylate downstream factors.3,4 Ca2+ signals are highly dynamic, exhibiting complex spatiotemporal forms such as Ca2+ transients that differ in...
Inter-membrane control of junctional InsP3 receptors by PIP2
Keywords calcium signals inositol trisphosphate receptors phosphatidylinositol bisphosphate Get full text access Log in, subscribe or purchase for full access. References 1. Berridge, M.J. ... The versatility and universality of calcium signalling Nat. Rev. Mol. Cell Biol. 2000; 1:11-21 2. Baraniak, Jr., J.H. ... The intricate coupling between STIM proteins and Orai channels Curr. Opin. Physiol. 2020; 17:106-114 3. Thillaiappan, N.B. ...
Three-Dimensional Reconstruction of Partially Coherent Scatterers Using Iterative Sub-Network Generation Method
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Identification of Glucosidase II that regulates STIM1 activation dynamics
Abstract The ubiquitous presence of stromal interaction molecule (STIM), endoplasmic reticulum (ER) Ca2+ sensors, plays a crucial role for maintaining Ca2+ homeostasis and signaling in mammalian cells by linking ER Ca2+ depletion with extracellular Ca2+ influx. Although recent advancements have shed light on glycosylation in STIM proteins, further exploration of deglycosylation enzyme modification and its role remains limited by methodological constraints.
CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes - Nature Chemical Biology
Abstract Ferroptosis is iron-dependent oxidative cell death. Labile iron and polyunsaturated fatty acid (PUFA)-containing lipids are two critical factors for ferroptosis execution. Many processes regulating iron homeostasis and lipid synthesis are critically involved in ferroptosis. However, it remains unclear whether biological processes other than iron homeostasis and lipid synthesis are associated with ferroptosis.
An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1 - Nature Communications
Abstract Ca2+ signal-generation through inter-membrane junctional coupling between endoplasmic reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but undefined mechanism. We identify two unusual overlapping Phe-His aromatic pairs within the STIM1 apical helix, one of which (F394-H398) mediates important control over Orai1-STIM1 coupling. In resting STIM1, this locus is deeply clamped within the folded STIM1-CC1 helices, likely near to the ER surface.
The changes of phospholipid degradation in sea urchin gonads (Glyptocidaris crenularis) during cold storage at 4°C
CONFLICT OF INTEREST STATEMENT All authors declare no conflicts of interest. REFERENCES 1, , , & (2012). Oxidative degradation and non-enzymatic browning due to the interaction between oxidised lipids and primary amine groups in different marine PL emulsions. Food Chemistry, 135(4), 2887–2896. 2, , , , & (2003). Polyunsaturated fatty acid profiles of whole-body phospholipids and triacylglycerols in anadromous and landlocked Atlantic salmon (Salmo salar L.) fry.
Role of STIM1 in the Regulation of Cardiac Energy Substrate Preference
1. Introduction To maintain an optimal contractile function, the heart has a high demand for energy substrates to continuously form energy-rich phosphate bonds (i.e., intracellular adenosine triphosphate, ATP) [1].
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