Younji Sim on Muck Rack

Younji Sim

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Articles

The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells - Nature Communications

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By Suyeon Kim, Kyung-Mi Lee, Cassian Yee, Eun-Woo Lee, Young-Chae Chang, Da-Young Yoon, Younji Sim
| Nature Verified
Abstract During cancer immunoediting, cancer cells deregulate cell death executioner mechanisms to escape immunotherapy-induced antitumor immunity. Ferroptosis, a type of regulated necrosis triggered by lipid peroxidation, plays a pivotal role in the anti-tumor activity of T cell-based immunotherapies; however, mechanisms for the modulation of ferroptosis in immune-refractory tumor cells are unclear.
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