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Cassian Yee on Muck Rack

Cassian Yee

Houston
As seen in: Nature, Wiley Online Library, The BMJ, U.S. News and World Report, Cell Press, The Journal of Clinical Investigation, Texas Medical Center
bye bye twitter/X. Hello Bluesky. same handle : tcellsrus. same dry take on life, science and Canadians. bsky.app/profile/tcellsrus.bsky.social
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Articles

Deciphering small sequence differences in T cell receptor-antigen pairing

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By Yi Han, Yuqiu Yang, James Z Zhu, Farjana Fattah, Mitchell von Itzstein, Minying Zhang, Casey Bermack, Peixin Jiang, Shailbala Singh, Yanhua Tian, Yifei Hu, Yafang Deng, Xiongbin Kang, Donghan M. Yang, Jialiang Liu, Chaoying Liang, Indu Raman, Chengsong Zhu, Olivia Xiao, Jonathan E. Dowell, Jade Homsi, Sawsan Rashdan, Ke Pan, Shengjie Yang, David Hsiehchen, Fangjiang Wu, John Heymach, don gibbons, Junzhou Huang, Jianjun Zhang, Cassian Yee, Alexandre Reuben, David E. Gerber, Tao Wang, Yaming Xue, Mary E. Gwin, Yvonne Gloria- McCutchen
| Nature Verified
Abstract T cells have important functions in development and disease processes through T cell receptor (TCR)-dependent activities. Many tools were developed to predict the binding between TCRs and antigens. However, one of the uncertainties is whether such tools can decipher how small changes in the TCRs or antigenic peptides contribute to binding. We develop a deep learning model, pMTnet-omni, which not only predicts the binding vs.
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The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells - Nature Communications

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By Suyeon Kim, Kyung-Mi Lee, Cassian Yee, Eun-Woo Lee, Young-Chae Chang, Da-Young Yoon, Younji Sim
| Nature Verified
Abstract During cancer immunoediting, cancer cells deregulate cell death executioner mechanisms to escape immunotherapy-induced antitumor immunity. Ferroptosis, a type of regulated necrosis triggered by lipid peroxidation, plays a pivotal role in the anti-tumor activity of T cell-based immunotherapies; however, mechanisms for the modulation of ferroptosis in immune-refractory tumor cells are unclear.
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Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

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By Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa Huang, Zhou Jiang, Jian Hua Gao, Shuang Peng, Tina Nguyen, Menuka Karki, Cassian Yee, Jared K. Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M. Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael Curran, Maria A. Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin
| Cell Press Verified
Keywords sickle cell disease renal medullary carcinoma ferroptosis genomic architecture alteration Hi-C H2S SLC7A11 SMARCB1 immune checkpoint inhibitors CD8+ T cells Introduction Sickle cell disease (SCD), the most prevalent inherited blood disorder,1 arises from the homozygous HbS mutation (GAG>GTG: βGlu6Val), causing hemoglobin abnormalities that make red blood cells (RBCs) assume a sickle or crescent shape.2 Individuals with SCD have RBCs prone to hemolysis, leading to vaso-occlusive...
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