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Yousra El Ghaleb on Muck Rack

Yousra El Ghaleb

As seen in: Nature, Cell Press
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Articles

CaV1.1 voltage-sensing domain III exclusively controls skeletal muscle excitation-contraction coupling - Nature Communications

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By Monica L. Fernández-Quintero, Yousra El Ghaleb, Klaus R. Liedl, Petronel Tuluc, Marta Campiglio, Simone Pelizzari, Martin C. Heiss
| Nature Verified
Abstract Skeletal muscle contractions are initiated by action potentials, which are sensed by the voltage-gated calcium channel (CaV1.1) and are conformationally coupled to calcium release from intracellular stores. Notably, CaV1.1 contains four separate voltage-sensing domains (VSDs), which activate channel gating and excitation-contraction (EC-) coupling at different voltages and with distinct kinetics. Here we show that a single VSD of CaV1.1 controls skeletal muscle EC-coupling.
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Ion-pair interactions between voltage-sensing domain IV and pore domain I regulate CaV1.1 gating

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By Yousra El Ghaleb, Monica L. Fernández-Quintero, Stefania Monteleone, Petronel Tuluc
| Cell Press Verified
Abstract The voltage-gated calcium channel CaV1.1 belongs to the family of pseudo-heterotetrameric cation channels, which are built of four structurally and functionally distinct voltage-sensing domains (VSDs) arranged around a common channel pore. Upon depolarization, positive gating charges in the S4 helices of each VSD are moved across the membrane electric field, thus generating the conformational change that prompts channel opening.
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