On June 24, the U.S. Food and Drug Administration (FDA) approved the combination of palbociclib (Ibrance) plus trastuzumab, with or without pertuzumab (Perjeta), and endocrine therapy as a maintenance treatment for adults with hormone receptor (HR)-positive, HER2-positive locally advanced or metastatic breast cancer after induction therapy. Regulators based their decision on results from the randomized, open-label PATINA clinical trial.