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Keywords multimodal spatial transcriptomics trinucleotide repeats Huntington’s disease protein aggregation neurodegeneration somatic repeat expansion Introduction Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the huntingtin gene (HTT), with more than 40 CAGs in exon 1 of HTT being fully penetrant.1,2 The expanded CAG tract encodes an elongated polyglutamine stretch that promotes mutant HTT misfolding and aggregation.1,2 Human HD brains show abundant...
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