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Yuao Yan on Muck Rack

Yuao Yan

As seen in: Nature
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Articles

LGR5-positive fibroblasts orchestrate skin mechanoadaptation through JAK1 modulation

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By Qiaoyu Fu, Nuo Chen, Yidan Sun, Yu Cheng, Chen Wang, Yin Feng Li, Tingting Yu, Yu Bu, Lifang Lei, Yining Chen, Zhen Li, Peiying Zhu, Caibing Wang, Liang Zhang, Caiyue Liu, Qingfeng Li, Luwen Xu, Yuao Yan, Wenwan Zhang
| Nature Verified
Abstract Mechanical adaptation is a fundamental yet poorly understood process in stromal tissue biology. Here, we identify a population of LGR5+ mechanically induced regulatory fibroblasts (LGR5+ MIRFs) in mouse and human dermis, whose induction requires a YAP/AP-1-dependent transcriptional program. LGR5+ MIRFs channel mechanical input toward adaptive tissue remodeling by coordinating extracellular matrix reorganization while restraining inflammation.
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