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Yining Chen on Muck Rack

Yining Chen

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Articles

Diet Quality and Physical Activity at 3–4 Years Following a Hypertensive Pregnancy: A Blood Pressure Postpartum Cross-Sectional Sub-Study

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By Yining Chen, Megan L. Gow, Katie Harris
| Wiley Online Library Verified
1 Introduction Hypertensive disorders of pregnancy (HDP), complicate 5%–10% of pregnancies worldwide [1], including chronic hypertension, gestational hypertension, pre-eclampsia, and preeclampsia superimposed on chronic hypertension [2].
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Metastasis enables immunogenicity through migrasome-mediated antigen release

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By Dong Jiang, Jinzhao He, Renxiang Xie, Minghui Shi, Siyuan Liu, Bingjie Yang, Xiaoyu Tao, Yining Chen, Lin Jiao, Xiaoyu Feng, Li Yu, Haohao Jia, Xiaojie Ruan, Yuhan Xiang
| Nature Verified
Abstract Antigen release is a critical step in initiating antitumor immune responses, yet its regulation during metastasis is not well understood. Here we show that circulating tumor cells undergoing vascular migration produce migrasomes that serve as a metastasis-specific mechanism of antigen release.
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LGR5-positive fibroblasts orchestrate skin mechanoadaptation through JAK1 modulation

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By Qiaoyu Fu, Nuo Chen, Yidan Sun, Yu Cheng, Chen Wang, Yin Feng Li, Tingting Yu, Yu Bu, Lifang Lei, Yining Chen, Zhen Li, Peiying Zhu, Caibing Wang, Liang Zhang, Caiyue Liu, Qingfeng Li, Luwen Xu, Yuao Yan, Wenwan Zhang
| Nature Verified
Abstract Mechanical adaptation is a fundamental yet poorly understood process in stromal tissue biology. Here, we identify a population of LGR5+ mechanically induced regulatory fibroblasts (LGR5+ MIRFs) in mouse and human dermis, whose induction requires a YAP/AP-1-dependent transcriptional program. LGR5+ MIRFs channel mechanical input toward adaptive tissue remodeling by coordinating extracellular matrix reorganization while restraining inflammation.
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