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Yining Chen

As seen in: Nature, Wiley Online Library, PLOS, Frontiers, MDPI, PNAS, ACS Publications, Royal Society of Chemistry, BioRxiv, Cell Press and
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Articles

Assessing the Impact of MULLET AI System on Focal Liver Lesion Detection: A Multicenter, Multi-reader, Multi-case Clinical Trial

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By Zhongquan Sun, Yining Chen, Hongfan Ding, Ying Chen, Haoze Cao, Xin Han, Wanyi Chen, Lei Wu, Feng Fang, Fan Wu, Jiajun Bu, Yuan Ding, Weilin Wang, Lianyue Yang
| Nature Verified
Abstract Early detection of focal liver lesions is critical for patient outcomes, but current imaging techniques have limitations. This study developed MULLET, an AI system using contrast-enhanced CT, and assessed its performance in assisting radiologists with FLL detection and characterization. A retrospective multicenter, multi-reader, multi-case trial was conducted, in which 10 radiologists independently interpreted 375 patients’ clinical images with and without MULLET assistance.
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Customizing Ferrocene Units into Atomically Precise Cu 11 Clusters for Boosting Oxygen Reduction to H 2 O 2 Click to copy article link Article link copied!

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By Xiaoyang Hu, Yan Sun, Yining Chen
| dx.doi.org
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NEK8 kinase-mediated lactate increase impairs antitumor immunity decreasing radiotherapy sensitivity in colorectal cancer

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By Mingzhou Li, Jieqiong Wu, Xin Zou, Yining Chen, Junfeng Qiu, Yifang Li, Li Wang, Feifei Wang, Hongxia Zhang, Jinghao Huang, Zilong Chen, Bingyu Xu, Yunfei Ni, Huayu Cai, Fangyi Han
| Nature Verified
Abstract Radiotherapy effectively treats colorectal cancer (CRC), but local recurrence remains common and abscopal effects—regression of tumors distant from irradiated sites—are rarely observed even with immune checkpoint inhibitors. Here we show that the protein kinase NEK8, highly expressed in CRC, promotes radioresistance by suppressing anti-tumor immunity. In radiation-resistant tumors, NEK8 phosphorylates lactate dehydrogenase A (LDHA), driving lactate overproduction.
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