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Yuemin Celina Chee on Muck Rack

Yuemin Celina Chee

As seen in: Cell Press
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Articles

Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche

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By Leibniz-Institute, Yuemin Celina Chee, Jens Pahnke, Ralph Bunte
| Cell Press Verified
The gut absorbs dietary nutrients and provides a barrier to xenobiotics and microbiome metabolites. To cope with toxin exposures, the intestinal epithelium is one of the most rapidly proliferating tissues in the body. The stem cell niche supplies essential signaling factors including Wnt proteins secreted by subepithelial myofibroblasts. Unexpectedly, therapeutically effective doses of orally administered PORCN inhibitors that block all Wnt secretion do not affect intestinal homeostasis.
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