Yuhki Nakatake on Muck Rack

Yuhki Nakatake

As seen in: Cell Press
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Articles

Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors

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By Shigeru B.H. Ko, Alexei A. Sharov, Yuhki Nakatake, Shunichi Wakabayashi
| Cell Press
Highlights • We examine the state changes of hESCs by overexpressing 714 transgenes individually • Nearly all genes, including heterochromatin genes, are perturbed by these transgenes • Transcription factors are grouped for hESC differentiation into specific lineages Summary Transcription factors (TFs) play a pivotal role in determining cell states, yet our understanding of the causative relationship between TFs and cell states is limited.
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