Yuki Matsubara
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Telisotuzumab adizutecan for metastatic colorectal cancer: a c-MET-targeted antibody–drug conjugate with a topoisomerase inhibitor payload
ABSTRACT Introduction Metastatic colorectal cancer (mCRC) remains a disease of significant unmet need, particularly for patients with refractory disease and limited targeted treatment. However, c-MET protein overexpression, which has been associated with poor prognosis, represents an emerging therapeutic target. Telisotuzumab adizutecan (Temab-A) is a novel antibody–drug conjugate designed to deliver a potent topoisomerase 1 inhibitor payload to c-MET-expressing tumor cells.
Ramucirumab‐containing chemotherapy for patients with gastrointestinal neuroendocrine carcinoma refractory/intolerant to platinum‐based chemotherapy: A multicenter observational retrospective study (WJOG13420G)
CI confidence interval DCR disease control rate ECOG PS Eastern Cooperative Oncology Group Performance Status FTD/TPI trifluridine/tipiracil GI-NEC gastrointestinal neuroendocrine carcinoma HR hazard ratio IPW inverse probability weighting NEC neuroendocrine carcinoma NEN neuroendocrine neoplasm ORR objective response rate OS overall survival PFS progression-free survival RAM ramucirumab VEGF vascular endothelial growth factor VEGFR-2 vascular endothelial growth factor receptor 2 WHO World...
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