Yunde Zhao

Abstract There remains a critical need for the precise control of CRISPR (clustered regularly interspaced short palindromic repeats)-based technologies. Here, we engineer a set of inducible CRISPR-based tools controllable by focused ultrasound (FUS), which can penetrate deep and induce localized hyperthermia for transgene activation. We demonstrate the capabilities of FUS-inducible CRISPR, CRISPR activation (CRISPRa), and CRISPR epigenetic editor (CRISPRee) in modulating the genome and epigenome.

Retraction to: Nature Communications https://doi.org/10.1038/s41467-021-24195-5, published online 22 June 2021. We retract the article cited above because genotyping results from recent experiments are not consistent with the conclusions presented in the paper. We recently genotyped a selection of F2 plants in order to identify plants to use for an introgression experiment.

Michael Mudgett Michael Mudgett Affiliations Section of Cell and Developmental Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0116, USA Search for articles by this author Yunde Zhao Yunde Zhao Correspondence Corresponding author Affiliations Section of Cell and Developmental Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0116, USA Search for articles by this author DOI:https://doi.org/10.1016/j.cub.2022.03.008 Summary...