Yurie Maeda

Keywords tissue clearing artificial intelligence in situ hybridization light-sheet microscopy histology human brain immediate early gene transcriptome mRNA volumetric imaging Introduction Understanding the function of an organ as an integrated network of distinct cell types is a central challenge in advancing medical science. Abnormal molecular events or cell loss can disrupt healthy communication between cells in a tissue, resulting in developmental defects and/or disease.

Abstract During the differentiation process of neurons, their gene transcription pattern changes according to both intrinsic and extrinsic stimuli-induced programs. Chromatin regulation at regulatory elements is involved in this precise control of gene expression. However, developmental changes in chromatin accessibility of the cortical neurons in vivo are less understood, partly because there is no convenient method to genetically label neurons of a specific lineage.

Analysis: A frugal approach to innovation may be a way to align our planet's financial, social and sustainable needs By Kevin Dominic Delaney and Yurie Maeda, TU Dublin Many stories have been told of how used cotton flour sacks were boiled and reused to provide bed linen for children in post-war Ireland. Even one of our grandmothers is known to have done this.