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Yuying Fan

As seen in: Nature, Wiley Online Library, Taylor & Francis Online, Royal Society of Chemistry
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Articles

Glycoprotein-induced phase separation drives unconventional secretion of galectin-3

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By Zihan Zhao, Zhen He, Hongming Gu, Andong Zhou, Yibing Wang, Jie Geng, Xuejiao Xu, Menghui Wang, Yuying Fan, Hairong Cheng, Lin Sun, Kevin H. Mayo, Avraham Raz, Yifa Zhou, Zhaoyi Liang, Chunyao Li, Guihua Tai
| Nature Verified
Abstract The mechanism of unconventional protein secretion remains an unresolved issue. Here, we describe an unconventional protein secretion pathway for galectin-3 that is mediated by phase separation and condensation. Using four lysosomal damage models, we observed a rapid, pronounced release of galectin-3 in large, non-exosomal particles. This secretion is driven by glycoprotein-induced galectin-3 phase separation and is independent of pyroptosis and secretory autophagy.
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A latent profile analysis of hierarchical management of supportive care needs in patients undergoing maintenance hemodialysis

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By Xue Li Verified, Hongyi Li, Jingshu Li, Yuying Fan
| Nature Verified
Abstract Previous studies have shown that the maintenance hemodialysis (MHD) severity is pyramidal, with variations in self-management capabilities and supportive care needs generated by different patients during daily care procedures. This study aimed to explore the potential categories of self-management abilities and supportive care needs of patients undergoing MHD to inform the development of personalized intervention programs.
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Spatial Electron Density Modulation by Engineering Ordered Built‐in Electric Fields for Efficient and Stable Water Splitting

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By Siyu Wang, Laiyu Luo, Yu Fu, Yuying Fan
| Wiley Online Library Verified
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm71605-sup-0001-SuppMat.docx8.1 MB Supporting Information References 1, , , , , , , , , , , , , Nature 2025, 639, 360. 2, , , , , , , , J. Am. Chem. Soc. 2025, 147, 15448. 3a) , , , , , , , , , Angew. Chem., Int. Ed. 2025, 64, 202424195; b) , , , , , , , , , , , , , , Angew. Chem., Int. Ed. 2025, 64, 202421640; c) , , , Coord. Chem. Rev. 2025, 534, 216603. 4, , , , , , , , , , , , J. Am. Chem. Soc.
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