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Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation Amy L. Palmer, Annemieke de Jong, Yves Leestemaker, Paul P. Geurink, Ruud H. Wijdeven, Huib Ovaa, Brian P. Dolan The Journal of Immunology February 1, 2018, 200 (3) 928-936; DOI: 10.4049/jimmunol.1700273
Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation Amy L. Palmer, Annemieke de Jong, Yves Leestemaker, Paul P. Geurink, Ruud H. Wijdeven, Huib Ovaa, Brian P. Dolan The Journal of Immunology December 27, 2017, ji1700273; DOI: 10.4049/jimmunol.1700273
During an immune response to microbial infection, CD8+ T lymphocytes can undergo asymmetric division, giving rise to daughter cells that exhibit distinct tendencies to adopt the terminal effector and memory fates. Here we show that ‘pre-effector’ and ‘pre-memory’ cells arising from the first CD8+ T cell division in vivo exhibit low and high rates of proteasome degradative activity, respectively.
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