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Zaheenul Islam on Muck Rack

Zaheenul Islam

As seen in: Color Research & Application, MDPI
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Articles

SARS-CoV-2 Syncytium under the Radar: Molecular Insights of the Spike-Induced Syncytia and Potential Strategies to Limit SARS-CoV-2 Replication

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By Hashim Ali, Asma Naseem, Zaheenul Islam, Zaheenul Islam Siddiqui
| MDPI
1. Introduction Cell–cell fusion events occur in many physiological processes, including fertilisation, development, immunity, and astrocytes, which allow the sharing of cellular contents, forming functional syncytia [1,2,3]. However, the fusion of cells which do not fuse naturally leads to several human diseases, including preeclampsia, myopathies, male infertility, cancer, and neurodegeneration [4,5,6,7].
Open in Who Shared Issue with article?

A comparative study of hepatitis B virus X protein mutants K130M, V131I and KV130/131MI to investigate their roles in fibrosis, cirrhosis and hepatocellular carcinoma - Siddiqui - 2017 - Journal of Viral Hepatitis - Wiley Online Library

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By Syed F. Ali, Zaheenul Islam, Sabihur Rahman, Syed Naqui
| Color Research & Application Verified
Hepatitis B virus (HBV) genomic mutations A1762T, G1764A and AG1762/1764TA cause production of HBV X protein (HBx) mutants, namely K130M, V131I and KV130/131MI. These mutations are important biomarkers for the development of cirrhosis and hepatocellular carcinoma (HCC) in chronic HBV patients. The present study comparatively analyzes the impact of intracellular expression of HBx mutants on HCC cell line Huh7.
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