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Zahraa Sabra on Muck Rack

Zahraa Sabra

As seen in: BioRxiv, JNeurosci, eLife
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Articles

GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation

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By Carlos Gonzalez-Islas, Zahraa Sabra, Ming-fai Fong, Pernille Yilmam
| eLife
eLife assessment This is an important study that brings insight into mechanisms that underlie regulation of GABAergic transmission in response to changes in activity. The authors present solid data supporting the premise that action potential firing rather than excitatory synaptic strength is a key determinant of GABAergic synaptic inputs.
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GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation

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By Carlos Gonzalez-Islas, Zahraa Sabra, Ming-fai Fong, Pernille Bülow
| BioRxiv
Abstract Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity. However, recent findings have forced us to reconsider this idea as several studies suggest AMPAergic scaling is not directly triggered by changes in spiking.
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GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation.

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By Carlos Gonzalez-Islas, Zahraa Sabra, Ming-fai Fong, Pernille Bülow
| BioRxiv
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