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You are already at the latest version In recent years, rapid progress in autonomous driving has been achieved through advances in sensing, control, and learning. However, as the complexity of traffic scenarios increases, ensuring safe interaction among vehicles remains a formidable challenge. Recent works combining artificial potential fields (APF) with game-theoretic methods have shown promise in modeling vehicle interactions and avoiding collisions.
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Parkin, a ubiquitin E3 ligase, is mutated in most cases of autosomal recessive early onset Parkinson disease. It was discovered that Parkin is also mutated in glioblastoma and other human malignancies and that it inhibits tumor cell growth. Here, we identified pyruvate kinase M2 (PKM2) as a unique substrate for parkin through biochemical purification. We found that parkin interacts with PKM2 both in vitro and in vivo, and this interaction dramatically increases during glucose starvation.
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